Sequenom's MassARRAY ® system enables sensitive and rapid somatic mutation profiling in solid tumors or cell lines. Our validation studies revealed mutations in most of the oncogenes analyzed ...

Somatic mutations take place in non-reproductive cells. Many kinds of somatic mutations have no obvious effect on an organism, because genetically normal body cells are able to compensate for the ...

The way in which blood stem cells evolve over a lifespan differs greatly between humans and mice, new research reveals. The ...

Acquired DNA mutations found in the SERPINA1 gene can protect liver cells from damage in patients with alpha-1 antitrypsin ...

Neurons collected from brain lesions in MS patients were found to accumulate new genetic mutations faster than healthy nerve ...

Learn about our Editorial Policies. Researchers make hiPSCs by harvesting somatic cells—often from skin—from a person and then reprogramming them to enter an embryonic-like state. Nik-Zainal says that ...

The new technique, called STRACK, allows monitoring of the evolution of each cell before and after acquiring oncogenic mutations. Myeloid leukaemias are among the most aggressive blood cancers and ...

Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key ... which block the ability of cells, including cancer cells, to repair DNA damage, in ...

as well as cell lineage (i.e. somatic mtDNA and nuclear mutations). In addition to resolving the functional heterogeneity of immune cells throughout the body, we hope to help translate our basic ...

Scientists from UCLA, the University of Toronto and the University of Melbourne have uncovered new genetic clues that explain why some prostate cancers remain slow-growing while others become ...

“It’s the first report of somatic mutations being passed [via reproductive cells] in an animal, as far as I can tell,” says Daniel Schoen, an evolutionary biologist at McGill University who was not ...