Scientists have finally captured footage of the microscopic machinery that allows our cells to copy DNA—a fundamental process ...

With the long-term goal of creating living cells from non-living components, scientists in the field of synthetic biology work with RNA origami. This tool uses the multifunctionality of the natural ...

By unveiling Pol-theta's DNA-bound structure—its active state—the study provides a blueprint for designing more effective cancer drugs. "We now have a much clearer picture of how Pol-theta ...

The experiments conducted by Kaspar Burger and his team show that the frequent occurrence of DNA double-strand breaks causes excessive methylation of NEAT1, which leads to changes in the NEAT1 ...

In 2006, Rothemund published the first paper on DNA origami, a technique that provides simple yet exquisite control ... acting as "staples" that hold the structure together. The technique can ...

A new twist: The molecular machines that loop chromosomes also twist DNA Dec 13, 2024 Single nucleosomes tracked in live cells during cell division using super-resolution microscopy ...

Figure 2. G4s contribute to cellular senescence. G4 structures contribute to nearly all of the senescence pathways in the cell, such as DNA damage, telomere shortening, chromatin structure, stress ...

Here we introduce a process called Improved Single-cell Genome Amplification (iSGA), in which the whole single-cell sequencing cycle is completed in a high-efficient and high-coverage manner, through ...

The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of ...

offer a new paradigm for understanding the initiation of DNA synthesis in eukaryotic replication. Their work suggests that Pol α has the ability to discriminate between different shapes of the ...