这篇研究揭示了 Rac1 和 STRIPAK 复合物在施万细胞（SC）发育中的关键作用及相关机制。 研究背景 在周围神经系统（PNS）发育过程中，施万细胞（SCs）的径向分选是轴突正确髓鞘形成的前提条件。SCs 通过将细胞质延伸插入轴突束，对单个轴突进行分类和髓鞘化 ...

Membranous SEMA4D on neutrophils bound to plexin B2 on endothelial cells, and this interaction decreased NET formation. Recombinant plexin B2 suppressed neutrophil Rac1 activation through SEMA4D’s ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Last but not least, there’s a new heavyweight Classic White T-shirt (AUD$99.95) that’s piqued our interest. You’ll want to make sure your denim is thoroughly worn in before wearing this one (to avoid ...

为解决糖尿病伤口愈合困难的问题，解放军总医院的研究人员开展了关于 NETs 对糖尿病伤口愈合影响的研究。结果发现 NETs 经 PI3K/Rac1 通路影响巨噬细胞吞噬功能，阻碍伤口愈合。该研究为治疗提供新策略，值得科研读者一读。 在当今社会，随着生活水平的提高 ...

Angiopep-2 (Ang2) is an oligopeptide that can target the blood–brain barrier. Through single-cell sequencing and immunofluorescence experiments, we confirmed that the expression of LRP-1, the targeted ...

Consequently, leukocytes cross the junction by migrating underneath the protruding endothelial cell. These protrusions depend on Rac1 activity and by using a photo-activatable Rac1 probe, we could ...

Protein localization in cells has been analyzed by fluorescent labeling using indirect immunofluorescence ... protein localizations from single staining, which would be useful for detecting the ...

Immunofluorescence staining is the most frequently applied technique to detect and visualize various molecules in biological samples. Many protocols can be found in the literature and the websites of ...

Inside the nucleus of a cell, the DNA is wound around histone proteins. This forms a structure called chromatin that allows the long DNA strands to fit inside the cell. Variations in chromatin ...