Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Genetics and Molecular Biology considera contribuições que apresentem os resultados de pesquisas originais nas áreas de genética, evolução e disciplinas científicas relacionadas. Genetics and ...

Mar. 4, 2025 — A vivid new image is taking shape in the world of cell biology: Imagine bacteria adhering to the surface of a cell, perhaps at the site of an injury or wound. In response ...

His scientific history began in the 60s when he approached molecular biology with the study of tRNA in the bacterium Streptomyces fradiae (Trentalance and Amaldi, 1965) but it was consolidated during ...

"AlphaFold is now routinely used in many biology labs. NuFold would be an RNA version of AlphaFold. So, in a way, we're extending the breakthrough of AlphaFold into the world of RNA, which has ...

Representing the most referenced spatial biology technology in the industry, RNAscope provides an unprecedented single-cell view of disease pathology and therapeutic response across a wide range ...

Christopher Burge, the Uncas and Helen Whitaker Professor of Biology at MIT, is the senior author of the study, which appears today in Nature Communications. RNA splicing, a process discovered in ...

Understanding how RNA folds into functional structures requires methods that can systematically assess how sequence perturbations affect RNA structure and function. Here, the authors develop a ...

In (+)-stranded RNA viruses, RNA is the sole genetic material. Because infected host cells ordinarily lack RNA-dependent RNA polymerase (RdRp) activity, these RNA viruses encode a replicative ...

The RNA Biology and Molecular Therapeutics Group works within the multidisciplinary environment of the Division of Cancer Therapeutics to identify novel targets for drug discovery and to support the ...

Gain the core competencies and skills needed to become a professional biologist. This flexible BSc lets you combine a broad base of biological scientific knowledge with a chosen specialism, so you can ...

The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs ...