Here we show that pyrimidine nucleotides can also bind and inhibit its proton-conducting activity. All nucleotides bound in a pH-dependent manner, with the highest binding affinity observed for ATP, ...

The phosphate groups are closely packed about the axis of the molecule, with the pentose residues surrounding them, and the purine and pyrimidine groups projecting radially, their planes being ...

转录中的随机波动（噪声）会产生大量的细胞间变异，但在缺乏通用噪声调节方法的情况下，噪声的生理作用仍然难以确定。之前的单细胞 RNA 测序 (scRNA-seq) 表明，嘧啶碱基类似物 (5'-iodo-2'-deoxyuridine, IdU) 通常可以放大噪声，而不会显着改变平均表达水平，但 ...

According to the latest information released by the Fungicide Resistance Action Committee (FRAC), over 30 fungicide selective targets have been identified and acknowledged in the field of fungicide ...

Single-molecule biophysics is the study of the dynamics and interactions of individual biomolecules to understand how they carry out their functions in living cells. For example, monitoring the ...

New generation of antibacterial agents are urgently needed in order to fight the emergence of multidrug-resistant bacteria. FtsZ is currently identified as a promising target for new types of ...

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by ...

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States Department of Biological Sciences, University at Albany, State University of New York, ...