Mutations in the PINK1 gene are the second most frequent cause of autosomal recessive parkinsonism after Parkin, and can represent a risk factor towards sporadic Parkinson's disease. The PINK1 ...

These findings suggest that POLG mutations can lead to impaired mitophagy and decreased lysosome formation via PINK1/Parkin-dependent pathway. Taken together, these data indicate that POLG mutations ...

An enzyme that helps clear damaged mitochondria can act as a molecular switch and potentially prevent neurons from dying.

High levels of active TBK1, however, negatively regulate AMPK, thus creating a negative feedback loop that can negatively affect autophagic flux. 3) Mitophagy: During PINK1-PARKIN-mediated mitophagy, ...

Parkin is well-positioned to capitalise on Dubai’s robust economic growth, ambitious urban expansion plans and corresponding population increase, the company’s CEO said. “Following a strong ...

Department of Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, People’s Republic of China ...

The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction ...

Parkin Police Chief Chris Miller. (Cross County Sheriff’s Department) Parkin Police Chief Chris Miller was arrested Tuesday morning on perjury charges. Miller took over as the Chief of Police in ...

Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.

2025年1月11日，中山大学陈洪忠、南开大学化学学院郭东升、中山大学药学院曾小伟共同通讯在Nature communications 上在线发表题为“Engineered hypoxia-responsive albumin ...