However, what types of heterogenous cancer cells in primary tumour and how they metastasise to the target organs remain largely undiscovered. Design We performed single-cell RNA sequencing and spatial ...

Hepatic fibrosis ... perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver, deposition of scar molecules, vascular and organ contraction, and ...

When the protein is not working correctly, it’s unable to help move chloride — a component of salt — to the cell surface. Without the chloride to attract water to the cell surface, the mucus in ...

Besides, the effect of natural products on hepatic fibrosis has not been widely recognized at home and abroad. Furthermore, drugs targeting a single anti-hepatic fibrosis target are prone ... all of ...

Although the immunologic and metabolic perspectives of fibrosis in the heart are being reported in the literature, they lack a comprehensive sketch bridging these two arenas and illustrating the ...

Bone-marrow-derived multipotent progenitor stromal cells — or mesenchymal stem cells ... However, inhibition of any one of these molecules does not result in a complete loss of the ...

The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...

January 2025 If you haven’t looked at what your cell phone bill might be under a ... But as always, most deals come with a catch. There isn’t one carrier or plan that we can recommend for ...

Cell phones can make it harder to fall and stay asleep. Research shows that people who use their phones at bedtime are more likely to have less and worse sleep than those who do not. In fact, one ...

Creating cancer therapies based around natural killer cells could offer similar levels of efficacy to CAR-T therapies, but at around one hundredth of the cost. Researchers at MD Anderson Cancer ...