The study shows that boosting mucin-type O-glycosylation in aged mice reinforces the blood-brain barrier and improves memory, ...

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

Bottlebrush Barrier. The glycocalyx layer (purple, left) that coats brain blood vessels consists of numerous glycoproteins, ...

You will be redirected to our submission process. Glycosylation, the enzymatic process of adding glycans to proteins or lipids, plays a pivotal role in immune recognition and response modulation.

Department of Chemistry, University of Colorado, Boulder, Colorado 80309, United States ...

O-fucosylation, a type of protein glycosylation, uniquely occurs on specific protein domains, including the EGF domain in Notch. FUT10 and FUT11, enigmatic fucosyltransferases with weak or unknown ...

An effective HIV-1 vaccine must therefore elicit antibodies that can neutralize many variants of the virus. While broadly neutralizing antibodies (bnAbs) have been isolated from HIV-1 infected ...

但希望之光已然显现：研究者通过腺相关病毒（AAV）基因治疗，将衰老小鼠脑血管的糖萼厚度恢复83%，不仅逆转血管渗漏，更让20月龄老年鼠在迷宫测试中展现超越年轻组的空间记忆能力。这项颠覆性发现不仅重新定义了血脑屏障的防御机制，更为对抗阿尔茨海默病开辟了全新治疗维度：修复纳米级的糖萼结构，或将成为阻止大脑"塌方式衰老"的关键突破口。

After hours: March 13 at 7:59:58 PM EDT Loading Chart for O ...