Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

NADH, also known as nicotinamide adenine dinucleotide, is a crucial coenzyme present in every cell of our bodies, serving as an elemental source for energy production. It aids in turning the food ...

College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China ...

Panelists discuss exciting updates on Bruton tyrosine kinase (BTK) inhibitors from the 2024 American Society of Hematology (ASH) Annual Meeting and Exposition, highlighting emerging data that may ...

Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, Illinois 62026, United States ...

In IMM, NADH and FADH2 serve as electron donors ... adenosine monophosphate-activated protein kinase; PINK1, phosphatase and tensin homolog induced putative kinase 1; Opa1, optic atrophy 1; Mfn1/2, ...

This crystal structure of nearly full-length human cGMP-dependent protein kinase Iβ (PKG Iβ) provides convincing new insights into how in the absence of cGMP the activity of the catalytic domain is ...

ADAM17 indicates a disintegrin and metalloprotease 17; AT1R, angiotensin receptor type 1; Cav1, caveolin 1; ERK, extracellular signal–regulated kinase; HB-EGF, heparin-binding EGF-like growth factor; ...

Despite extensive research, the exact pathogenic mechanisms underlying SBMA remain elusive. In this study, we present evidence that Nemo-like kinase (NLK) promotes disease pathogenesis across multiple ...