Lactate can also be converted to lactoyl-CoA, which is involved in the lactylation of histone and non-histone proteins. HK-1, hemokinin-1; G6PD, glucose 6-phosphate dehydrogenase; PKM, glycolytic ...

PINK1 phosphorylates MIRO and activates Parkin mediated ubiquitination and degradation of MIRO. MFN1, mitofusin 1; MFN2, mitofusin 2; OPA1, optic atrophy 1; LRRK2, leucine-rich repeat kinase 2; VPS35, ...

Department of Pharmaceutical Engg.Tech, IIT-Banaras Hindu University,Varanasi, Uttar Pradesh 221005, India ...

Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to ...

One of the best studied signalling routes is the mitogen activated protein (MAP) kinase signal transduction pathway which plays a crucial role in many aspects of immune mediated inflammatory responses ...

Migratory locusts display striking phenotypical plasticity. Gregarious locusts at high density can migrate long distances and cause huge economic losses of crops. By contrast, solitary locusts at low ...

Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...