They also provided evidence to show that inhibition of PLECTIN inhibited HCC cell invasion and reduced metastatic outgrowth in the lung. Mechanistically, they suggested that PLECTIN inhibition ...

Using autochthonous and orthotopic mouse models we demonstrated that genetic and pharmacological inactivation of plectin potently suppressed the initiation and growth of HCC. Moreover, plectin ...

Pembrolizumab is under clinical development by Merck and currently in Phase II for Metastatic Hepatocellular Carcinoma (HCC). According to GlobalData ... for the treatment of patients with metastatic ...

Lung cancer liver metastases are tumors that form in the liver from cancer cells that have broken away from the primary cancer and spread through the blood or lymphatic system. The liver is a common ...

Amivantamab is under development for the treatment of non-small-cell lung cancer (NSCLC), recurrent squamous cell carcinoma of the head and neck (SCCHN), hepatocellular cancer (HCC), colorectal cancer ...

Hypoxia-induced YAP/HIF-1α signaling activation facilitates tumor cell growth, survival, and metastasis, and hypoxia is a central marker of HCC and its microenvironment. YAP/HIF-1α signaling is a ...

Ltd Animal Ethics Committee and in compliance with ethical standards and national guidelines [License number: SCXK-2024-Mi-032]. To investigate the impact of PB on BC lung metastasis (BCLM) in vivo, ...

However, its role in hepatocellular carcinoma (HCC) is unclear. Furthermore, small extracellular vesicles (sEVs, or exosomes) are critical mediators of tumourigenesis and metastasis, but the ...

We aimed to understand molecular mechanisms of the intertwined interactions between tumour stromal components in metastasis and to provide a new paradigm for PDAC therapy ... including oesophageal ...