BACKGROUND: Despite the high morbidity and mortality of heart failure with preserved ejection fraction (HFpEF), treatment ...

Institute of Medical Microbiology and Hygiene and Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University, Mainz 55131, Germany Institute of Infection ...

State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pharmacology and Chemical ...

affects multiple metabolic pathways, disrupts the mitochondrial homeostasis, inhibits the clearance of lipid autophagy, and promotes the ER stress. DNL, Lipid de novo synthesis; GLUT 2, Glucose ...

What is Pathway to Purdue Agriculture? Pathway to Purdue Agriculture is a partnership between the Purdue University College of Agriculture and Ivy Tech Community College-Lafayette designed to help ...

In addition, the end products of peroxisomal β-oxidation subsequently enter mitochondria for metabolism and energy production. FIGURE 6. VLCFA biosynthesis in mammalians. Acyl-CoA is first condensed ...

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty ...

The diversity of life on Earth is a result of continual innovations in molecular networks influencing morphology and physiology. Plant specialized metabolism produces hundreds of thousands of ...

In this study, we aimed to screen metabolomes of both healthy and subjects with abnormal obesity to identify potential metabolic pathways that may regulate the different metabolic characteristics ...