芦荟大黄素(Aloe-emodin)这种蒽醌类衍生物展现出令人惊喜的抗癌特性。在人类肝癌细胞系Hep3B中，它像精准的"分子开关"般激活AMP活化蛋白激酶(AMPK)，引发一系列连锁反应：先是促使微管相关蛋白轻链3(LC3-II)和p62从细胞质"搬家"到线粒体，接着显著提升线粒体内PTEN诱导激酶1(PINK1)和parkin的表达水平 ...

HCV infection has been shown to influence mitophagy. Kim et al. reported that HCV-infected cells exhibit a higher number of mitophagosomes compared to uninfected cells. The presence of HCV-induced ...

Introduction Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the ...

Derek Parkin OAM has accounting experience spanning over 40 years and across four continents, primarily in the public company environment. Mr Parkin was a national board member of the ICAA and has ...

Yorke Parkin and coach Saige Beaumont celebrate one of his three gold medal wins at the 2025 Special Olympics World Winter Games. Photo provided by Special Olympics Canada. Yorke Parkin, Revelstoke ...

BYRON, Minn. - Kathy J. Parkin, 70, Byron, Minn. died Friday, Jun. 13, in her home. A celebration of Kathy's life will be held on Sunday, June 22, 2025, from 1:00 – 4:00 PM at Ranfranz and Vine ...

Co-founder of Ethical Partners Funds Management, Nathan Parkin, will join the ASX-listed firm in the newly created position next week.

Ryan Parkin is a Chartered Accountant with almost 15 years spent in Europe and Australia. He has experience in mergers and acquisitions, capital raising and startups within the public and private ...

Dubai: Parkin has announced that public parking across Dubai will be free of charge during the Eid Al Adha holiday, from Thursday, June 5, to Sunday, June 8, 2025.

临床实践中神经退行性疾病患者日益增多，然而现有治疗手段较为有限。许多患者长期饱受疾病折磨，生活质量大幅下降，而传统治疗方法只能在一定程度上缓解症状，无法从根本上遏制疾病进程。这促使作者决心深入探索神经退行性疾病的发病机制，期望从自噬这一关键细胞降解途径入手，为寻找更有效的干预策略提供新思路和希望。导 ...