G-protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors, which can be activated by an external signal such as a ligand. Binding of GPCRs and ligands in the plasma ...

Various signaling pathways guide the organization of cells and tissues in the body. Among these is the Bone Morphogenetic Protein (BMP) pathway, which plays a vital role in instructing early ...

The signaling pathways that mediate NGF-induced smooth muscle cell migration are not known. Because these cells express native PDGF-BB (Fan et al, unpublished data, 1999) and IGF-1 receptors (see ...

This study delves into the adverse effects of AVM, emphasizing oxidative stress induction in the Chinese mitten crab, Erocheir sinensis, and the role of the MAPK-CncC signaling pathway in mediating ...

Recent studies provide new insights into signaling by mutant KRAS, inhibitors of which have provided modest benefits for patients. Skip to main content The New England Journal of Medicine NEJM ...

Schematic illustration of bacterial chemotaxis signaling pathway, adapted from Alon et al.() and analyzed by Yi et al() as a feedback control moduleThe output, cell tumbling frequency, is determined ...

Kahn et al. demonstrate how TGFb signaling adds to the complex constellation of signaling pathways that regulates myofibroblasts during the formation of the alveolar wall. While TGFb signaling was ...

Scientists discover a new signaling pathway and design a novel drug for liver fibrosis. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 04 / 240426110048.htm ...

An activated microglial cell in the brain of cGAS/STING activated mice. [Gulen et al. Nature 02 August 2023. DOI: 10.1038/s41586-023-06373-1] Low-grade inflammation contributes to age-related ...

Reciprocally, ER stress regulates the PI3K/AKT/mTOR signaling pathway. Therefore, under pathologic conditions, the cross-talk between the mTOR and UPR signaling pathways during cellular stress can ...

Discovery of cross-species signaling pathway unlocks mysteries around parasite immunity and development Ticks recognize a cytokine from infected mammalian blood, triggering a defense against Lyme ...