Until now, doctors knew hepatic stellate cells mainly as drivers of liver fibrosis. The actual functions of this cell type have hardly been studied to date. Researchers have now determined that ...

The puzzle Starting with mouse livers treated with carbon tetrachloride (which models acetaminophen damage), Drasdo’s team built computational models of how liver lobules regenerate after damage.

The story begins with Etienne Sokal and Mustapha Najimi’s discovery of liver-derived progenitor cells in 2005. Sokal and Najimi discovered liver-derived cells expressing mesenchymal stem cell ...

Ongoing injury in the lobules, represented by inflammation ... as they may be in other forms of chronic liver disease. Finally, the liver biopsy is examined for fibrosis. Fibrosis in the liver ...