How might upregulating glycolysis cause neuron death? The authors showed that, under normal circumstances, neurons consume more glucose through the pentose phosphate pathway (PPP) — a metabolic ...

In neurons, only a small portion of glucose is consumed via the glycolysis pathway. At the same time, astrocytes provide nutrients to neurons and utilize glycolysis to metabolize glucose. These ...

The results show potential indications for PFKFB3 inhibitors. Using our proprietary molecular modelling tool, we designed a series of novel small molecule PFKFB3 inhibitors to target the fructose ...

PFKFB3-stimulated glycolysis is critical for the induction of human aGvHD, which can be rescued via PFKFB3 inhibition. Glucorticosteroids (GCs) ...

PFK158 is a potent small molecule inhibitor of PFKFB3 that is selectively cytotoxic to Ras-transformed epithelial cells and displays broad anti-tumor activity causing ~80% growth inhibition in several ...

Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...

Creative Proteomics announced the launch of a Glycolysis Pathway Analysis platform that incorporates LC-MS/MS metabolomics, stable isotope tracing, and computational flux modeling for a complete ...