News

In neurons, only a small portion of glucose is consumed via the glycolysis pathway. At the same time, astrocytes provide nutrients to neurons and utilize glycolysis to metabolize glucose. These ...
How might upregulating glycolysis cause neuron death? The authors showed that, under normal circumstances, neurons consume more glucose through the pentose phosphate pathway (PPP) — a metabolic ...
PFKFB3-stimulated glycolysis is critical for the induction of human aGvHD, which can be rescued via PFKFB3 inhibition. Glucorticosteroids (GCs) ...
The results show potential indications for PFKFB3 inhibitors. Using our proprietary molecular modelling tool, we designed a series of novel small molecule PFKFB3 inhibitors to target the fructose ...
Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...
PFK158 is a potent small molecule inhibitor of PFKFB3 that is selectively cytotoxic to Ras-transformed epithelial cells and displays broad anti-tumor activity causing ~80% growth inhibition in several ...
The researchers dubbed their new hybrid pathway non-oxidative glycolysis, or NOG. "This is a fundamentally new cycle," Bogorad said. "We rerouted the most central metabolic pathway and found a way ...
Using tools such as mouse genetics and stem cell-derived organoids, Takata plans to continue his study of how the glycolytic pathway and metabolism impact organ development. The findings from this ...
Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been ...
Creative Proteomics announced the launch of a Glycolysis Pathway Analysis platform that incorporates LC-MS/MS metabolomics, stable isotope tracing, and computational flux modeling for a complete ...