The glycolysis metabolic pathway plays an important role in securing the production of energy and biomass and the maintenance of redox homeostasis. Growing evidence indicates that the dysregulation of ...

Consistent with the glycolytic role of PFKFB3, silencing PFKFB3 decreased the expression of glycolytic ALDOC, ENO2, and ENO3 expression, confirming the inhibition of the glycolytic pathway. 12 The 84 ...

Additionally, by using Pfkfb3 knockout or overexpressing strategies and conducting experiments with cytokine stimulation or transplantation stress, they found that PFKFB3 governs cell cycle ...

6. In this study, their findings suggest that PFKFB3 is required for glycolysis of HSCs under stress, including transplantation. In Figure 7B, the results showed that donor-derived chimerism in PB ...

Pertinent avenues for exploration include the phenotypic ramifications of PFKFB3 upregulation, the implications of metabolic exhaustion arising from sustained glycolytic activity, and the modulation ...

3- conversation Fructose-6-P to Fructose-1,6- bisphosphate (Phosphofructokinase) Phosphofructokinase-1 (1-PFK) is an enzyme that converts fructose-6-phosphate to fructose-1,6-bisphosphate by utilizing ...

Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...

The following is the summary of “PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation” published in the January 2023 issue of Cellular and Molecular Gastroenterology and ...

In the current study, researchers demonstrated for the first time that T cells from acute graft-versus-host disease (aGvHD) patients preferentially depend on PFKFB3-stimulated glycolysis to meet ...

Along with VEGF, PFKFB3 plays an important role in sprouting angiogenesis by regulating endothelial tip-cell competition. Furthermore, PFKFB3-driven glycolysis reduces neurons’ antioxidative ability, ...