A key discovery was the activation of the HIF1α-HMOX1 axis, which drives excessive autophagy and ferritin degradation, leading to intracellular iron overload and lipid peroxidation, hallmarks of ...

The Role of Ferroptosis Inhibitors The authors discuss the use of ferroptosis inhibitors, such as ferrostatin-1, in assessing the relevance of ferroptosis in liver injury. Ferrostatin-1 and its ...

The application of ferroptosis inhibitors can alleviate the development of AD in both cellular and animal models. Herein, a series of dual-functional hydroxylated chalcone derivatives by ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

Mechanistically, ferric ammonium citrate (FAC) activates lipid peroxidation in primary lung epithelial cells, which was suppressed by ferroptosis inhibitors, ferrostatin-1 and liproxstatin-1.

Efficacy of plogosertib (CYC149462), a novel orally bioavailable PLK1 inhibitor, on patient-derived models of colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal ...

Triple-negative breast cancer (TNBC) is one of the most aggressive and difficult-to-treat forms of breast cancer, lacking targeted therapies due to its molecular characteristics. Tumor-associated ...

Melanoma, one of the most aggressive forms of skin cancer, often metastasizes to bones, causing severe bone loss, an increased risk of fractures, and significant pain. Bone metastasis is associated ...