This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

S7B). In TFEB KO cells, this increase of surface LAMP1 signal by SFN treatment was significantly reduced, suggestive of SFN-induced exocytosis in a TFEB-dependent manner. We also investigated the ...

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a paper in Nature ...

Synuclein also forms a perplexing web of interactions with lipids, trafficking machinery, and other regulatory factors (Wang and Hay, 2015). Moreover, the protein's effects on endocytosis, exocytosis, ...

Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

Biophysics is the study of physical phenomena and physical processes in living things, on scales spanning molecules, cells, tissues and organisms. Biophysicists use the principles and methods of ...

Virion binding to ACE2 for host cell entry leads to internalization of both via endocytosis, as well as activation of ADAM17/TACE, resulting in downregulation of ACE2 and loss of its protective ...

The maintenance of synaptic transmission requires that these vesicles be retrieved by a reverse process, i.e. endocytosis. How is this endocytic activity and subsequent formation of fusion-competent ...

Copyright 2025 The Associated Press. All Rights Reserved. Actor Gene Hackman arrives with his wife, Betsy Arakawa, for the 60th Annual Golden Globe Awards in Beverly ...

Mental health professionals no longer diagnose ADD. Instead, they diagnose one of three types of ADHD: inattentive, hyperactive-impulsive, or combined. Attention deficit hyperactivity disorder ...