Inhibitors of orotidine monophosphate decarboxylase (ODCase) have applications in RNA viral, parasitic, and other infectious diseases. ODCase catalyzes the decarboxylation of orotidine monophosphate ...

Novel tiazofurin adenine dinucleotide (TAD) analogues 25−33 containing a substituent at C2 of the adenine ring have been synthesized as inhibitors of the two isoforms of human IMP-dehydrogenase. The 2 ...

Inhibitors of DNA methylation can reactivate genes that have been silenced. Two examples of these types of drugs are 5-azacytidine and 5-aza-2′-deoxycytidine (Egger et al., 2004).

本研究揭示了补体成分C1QL1在乳腺癌中的抑癌作用机制。研究人员通过多组学分析发现，C1QL1通过促进HSP90α和VCP的泛素化降解，激活内质网应激 (ERS)/未折叠蛋白反应 (UPR)通路，从而诱导caspase依赖性凋亡。该研究为乳腺癌诊断提供了新的甲基化标志物，并为靶向ERS通路的治疗策略奠定理论基础。

BACKGROUND: Inhaled adenosine monophosphate (AMP) is thought to cause bronchoconstriction in asthmatic patients indirectly through mast cell mediator release. It may therefore be a more sensitive ...

The pathophysiology of thymidine kinase 2 deficiency (TK2d) stems from mutations in the TK2 gene, which impair mitochondrial DNA (mtDNA) synthesis and maintenance, leading to progressive energy ...

Benfotiamine is a synthetic form of vitamin B1. The human body readily converts benfotiamine into thiamine, which is essential for brain function and needed to meet energy demands. Benfotiamine ...