资讯

Leukemia - Absence of mutations in the deoxycytidine kinase ... deoxycytidine monophosphate (dCMP) kinase and nucleoside diphosphate (NDP) kinase. Ara-CTP inhibits DNA polymerase, ...
Again, dFdCTP suppresses inactivation of dFdCMP by inhibiting deoxycytidine monophosphate deaminase (DCTD). On the other hand, more than 90% of administered gemcitabine is converted, ...
The idea is that molecules such as deoxythymidine monophosphate and deoxycytidine monophosphate would be converted to those required for the synthesis of mitochondrial DNA.