The promise of genome editing to help understand human diseases and create new therapies is vast, but technological ...

Artificial human DNA, or synthetic DNA (synDNA), would be made without biological parents by instead using chemicals. SynHG ...

The collapse of DNA replication forks leads to the formation of single-ended DNA double-strand breaks. One would have assumed that these breaks would be repaired as soon as possible.

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and ...

Here we show the existence of abundant DNA double-strand breaks (DSBs) in hypermutating sequences. ... occurring either directly at, or 1–2 nucleotides away from, a mutation (Fig. 1C, D).

In this communication, we show that peptide nucleic acids (PNAs) with lengths of 15−20 nucleotides, when preorganized into a right-handed helix, can invade mixed-sequence double-helical B-form DNA ...

The promise of genome editing to help understand human diseases and create new therapies is vast, but technological limitations ...

Manipulating DNA repair proteins to improve gene editing outcomes. by Michelle Franklin, ... Although there's no double-stranded break, base editors do create a nick in one strand.

Nucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling (cGMP and cAMP), and are incorporated ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

The growing incidence of infectious diseases, cancer, and chronic illnesses has substantially increased the demand for ...