How is all of that DNA packaged so tightly into chromosomes and squeezed into ... may be highly irregular and not quite the uniform structure depicted in instructive drawings such as Figure ...

In a nutshell All modern humans share DNA from two ancient populations that split 1.5 million years ago and reunited through ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

These motors play distinct roles in manipulating chromosome structure. Swimming motors, similar to RNA polymerases—enzymes that copy DNA sequences into RNA—help expand and contract the ...

Members of the same species usually have DNA similar enough to have the same chromosomes and autosomes (chromosomes that don't code for sex-linked traits). In its structure, DNA contains a pattern ...

Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

MSK researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a ...

Pancreatic cancer is one of the deadliest cancers worldwide, with a five-year survival rate of 13%. This poor prognosis stems ...

The applied physicist explains how the structure of 52,000-year-old genes hint at the biology of an extinct animal ...

In the absence of DDM1 and RNAi, this TE doesn’t produce small RNAs, so the centromere is not methylated. These mutants also had few epigenetic tags on their histones, which contribute to the ...

Researchers have uncovered mechanisms by which mobile genetic elements integrate into the chromosomes of bacteria with linear genomes.