This three-step pathway involves the enzymes carboxylesterase, cytidine deaminase and thymidine phosphorylase (Figure 1), all of which are expressed in hepatic and tumor tissue. In particular the ...

They engineered CRISPR–cas9 fusion with cytidine deaminase enzyme that has the ability to be programmed with a guide RNA, without the cleavage of dsDNA, and facilitates directly conversion of cytidine ...

Rapid activation of adenosine monophosphate-activated protein kinase (AMPK) induces phosphorylation of mitochondrial-associated proteins, a process by which phosphate groups are added to regulate ...

Detecting danger is key to the survival and success of all species. Animal nervous and immune systems cooperate to optimize danger detection. Preceding studies have highlighted the benefits of ...

Remarkable progress has been made in recent years on the structural determination of proteins in the IgE network and on the functions and regulation of IgE. This is beginning to feed into IgE ...

核基因组突变是多种疾病的根源，而线粒体作为细胞内具有半自主功能的细胞器，拥有独立的基因组，其基因组突变同样与 ...

Both authors share equal and corresponding authorship. The helminth diseases schistosomiasis, opisthorchiasis, and clonorchiasis are highly carcinogenic. Trypanosoma cruzi has a dual role in cancer ...

Shortly after this publication, Bogdanove struck up a collaboration with Daniel Voytas, a plant geneticist at the University ...

The authors have demonstrated the use of adenine base editors delivered via adeno-associated viruses to introduce edits in the mitochondrial genome. The manuscript describes the methodology well, and ...

Drugs metabolized by cytidine deaminase Hydroxyurea Myelosuppression, hemolytic anemia, secondary malignancies, embryo-fetal toxicity, vasculitic toxicity, macrocytosis ...