Only data from patients who successfully received CAR T cells infusions were pooled in the study. Associations were identified between cellular kinetic parameters and product characteristics, ...

To create one of the most advanced immunotherapies in cancer, CAR-T cell therapies, scientists engineer immune T cells to carry a synthetic protein on their surfaces. This protein, called the ...

CAR-T cell therapy has revolutionized immunotherapy but its allogeneic application ... Although a very small number of cells is often obtained through this process, VST are polyclonal and contain both ...

Like other CAR-Ts, Calibr's therapy is manufactured from a patient's own T-cells, which are harvested and genetically modified to fight cancer before being reintroduced into the body.

Copyright: © 2025 Elsevier Ltd. Published by Elsevier Ltd. CAR T-cell therapies have revolutionised treatment of many diseases, but their expense means many patients ...

In the wake of its success in cancer therapy, adoptive transfer of engineered T cells modified with chimeric antigen receptors (CAR) for target recognition could now become a therapeutic option for ...

CAR T cells show contrasting approaches to killing cancer, with one sprinting for fast action and the other collaborating for endurance. Scientists are now focusing on adapting these cells to outsmart ...

We previously discovered 2 that H3K27M-mutant glioma cells express high levels of the cell-surface glycolipid GD2, and that chimeric antigen receptor (CAR) T cells engineered to target GD2 cleared ...

With a 6.2-liter LT1 V8 under the hood, the 2024 Camaro SS produced 455 hp and 455 lb-ft of torque. The V6-powered Camaro may have been enough for rental car fleets, but the big V8 was where all ...

图1. 肿瘤病人单细胞多组学与筛选鉴定到ETV7作为调控CD8 + T细胞命运的转录焦点，促进CD8 + T细胞的终末分化（耗竭）与功能缺失。靶向ETV7有效增强CAR-T杀伤实体瘤的效率。