Only data from patients who successfully received CAR T cells infusions were pooled in the study. Associations were identified between cellular kinetic parameters and product characteristics, ...

Like other CAR-Ts, Calibr's therapy is manufactured from a patient's own T-cells, which are harvested and genetically modified to fight cancer before being reintroduced into the body.

In the wake of its success in cancer therapy, adoptive transfer of engineered T cells modified with chimeric antigen receptors (CAR) for target recognition could now become a therapeutic option for ...

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IL-1 signaling in DCs promotes their ability to induce T cell activation, but also direct action of IL-1 on both CD4 + and CD8 + T cells, either alone or in synergy with prototypical polarizing ...