A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

Scientists discovered a cancer-fighting compound in mold from ancient tombs, revealing a powerful new drug against leukemia.

Single-cell CRISPR screening is a powerful method for biological discovery. Such screens genetically perturb many genes in parallel and use single-cell RNA sequencing to assess the transcriptomic ...

The rise of CRISPR-Cas9 and other gene-editing tools has revolutionized genetic engineering ... Moreover, the convergence of bioengineering with data analytics, artificial intelligence, and ...

CRISPR screens are untangling molecular mechanisms that drive biological processes with greater precision and detail. Lei Tang; Comments & Opinion 06 Dec 2024 Nature Methods. Volume: 21, P: 2226.

Acute myeloid leukemia (AML) is an aggressive cancer affecting the blood and bone marrow that progresses rapidly, making ...

Cells depend on the precise reading of DNA sequences to function correctly. This process, known as gene expression, ...

Kamena Kostova, Ph.D., Assistant Investigator at the Stowers Institute for Medical Research, has been named a 2025 Freeman ...

卵巢癌 (OC)腹膜转移机制不明导致患者预后极差。南开大学团队通过CRISPR/Cas9全基因组筛选发现NBL1基因在转移灶中显著高表达，证实其通过诱导腹膜上皮细胞间质转化 (EMT)并激活Jak/Stat3通路促进肿瘤转移。该研究颠覆了NBL1作为抑癌基因的传统认知，为靶向治疗提供新策略。