CRISPR screen of human stem cell derived MYC-driven medulloblastoma tumors reveal the mitochondria as a vulnerability [abstract]. In: Proceedings of the American Association for Cancer Research Annual ...

Mammalian cells are used to express complex biologics, such as multispecific antibodies. While multispecifics enable promising new strategies for treating human disease, their production at high ...

(A) Schematic of the decitabine CRISPR-Cas9 screen in HAP1 cells. (B) Upset plot of positively selected genes in the screen. Genes that were consistently identified in any two of Day 6, Day 8, or Day ...

Natural killer (NK) cells are pivotal in the innate immune response against cancer and viral infections, with their presence in tumors correlating to better patient outcomes in various cancers.

Lam et al., present a very intriguing whole genome CRISPR screen in Syrian Hamster cells as well as K562 cells to identify key genes involved in hypothermia-rewarming tolerance. Survival screens were ...

We started by testing 3 different mesothelin binders named SS1, 121, and M912. Our transposon vector also encodes for secretion of the cytokine IL15 for increased persistence and function of CAR-NK ...

A new CRISPR screen method developed at Scripps Research has the potential to improve studies into the genetic underpinnings of human diseases and disorders. The method was outlined in Cell, in a ...

This method leverages CRISPR-Cas9 technology and a readout, single-cell transcriptomic analysis, to measure its impact on a cell: one cell at a time. Using CRISPR-Cas9, scientists can make precise ...