Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

In this study, we developed a novel diagnostic tool targeting the speB gene of GAS, designated GAS-MCDA-CRISPR, for the simple, rapid, and sensitive diagnosis of GAS infections. The detection platform ...

Evercore ISI has upgraded CRISPR Therapeutics (NASDAQ:CRSP) to outperform from in line, citing upcoming catalysts. The investment firm said it was now including the CTX320 and CTX310 in vivo ...

To find out, collaborators at the Boyce Thomson Institute used CRISPR-Cas9 gene-editing technology to tweak one or both duplicates of a gene, and collaborators at Cold Spring Harbor grew the ...

Evercore ISI has upgraded CRISPR Therapeutics (NASDAQ:CRSP) to Outperform, citing multiple upcoming catalysts that could drive the stock higher. The firm is now factoring in CTX320 and CTX310 in ...

Evercore ISI analyst Liisa Bayko upgraded Crispr Therapeutics (CRSP) to Outperform from In Line with a price target of $99, up from $60. Upcoming key catalysts could “usher in a new era,” says ...

More information: Ryotaro Hashizume et al, Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf022 ...