Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

Of the remaining 7 patients without anti-CD4 antibodies at baseline, most (n=6) remained seronegative over the same period. Study limitations include reduced generalizability to patients with higher ...

Keywords: chronic graft-versus-host disease, CD4 + T cells, anti-CD4 monoclonal antibody, thymic recovery, immune tolerance Citation: Wang Z, Li R, Fu W, Cheng H, Zhang Y, Tang G, Yang J, Wang J and ...

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Autoimmunity against melanoma differentiation–associated gene 5 (MDA5) induces fibrotic interstitial lung disease (ILD) in mice. In detail, MDA5-specific CD4 + T cells and virus infection-stimulated ...

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Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in the HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)3] ... Indoline CD4-mimetic compounds ...

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Researchers depicted the correlations between receptor-binding domain (RBD)-selective proliferative memory CD4 T cells and neutralizing antibodies in COVID-19 vaccinees and convalescent patients.

Two markers, namely HLA-DR and CD38, were analyzed in the study to determine the recent activation of virus-specific CD4+ T cells. The findings revealed that the percentage of HLA-DR+ and CD38+ T ...