Mitochondrial ROS and its oxidation products are known to play a prominent role in inflammasome activation, whereas the role of NOX is highly dispensable (14). Mechanistic insight into the specific ...

Mitochondria are essential metabolic organelles that play an important role in maintaining cellular energy homeostasis through efficiently coupling the TCA cycle to the ETC. The TCA cycle, initiated ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

Mitochondrial membrane potential directly powers many critical functions of mitochondria, including ATP production, mitochondrial protein import, and metabolite transport. Its loss is a cardinal ...

2018). However, there is no adequate in vivo model demonstrating the importance of BAT glycolysis or glucose oxidation on adaptive thermogenesis. We will address this question in vivo by blocking ...