The endocrine cells confined in the islets of Langerhans are responsible for the maintenance of blood glucose homeostasis. In particular, beta cells produce and secrete insulin, an essential hormone ...
Dr Samet Sahin from the School of Engineering has received £406,000 funding to develop a simple tool to allow healthcare professionals to quickly and ...
Our perspective about glucose toxicity as it pertains to the pancreatic ß-cell is that the characteristic decreases in insulin synthesis and secretion are caused by decreased insulin gene expression.
Last year, CellTrans claimed the first FDA approval for a cell therapy for type 1 diabetes, Lantidra (donislecel) consisting of insulin-producing islet beta cells taken from deceased donors.
due to its ability to bind insulin growth factor (IGF). Noteworthily, it only shares about 20%–25% sequence homology with other proteins of the IGFBP family, while its ability to bind IGF was reported ...