Apoptosis and autophagy constitute the two self-destructive processes by which supernumerary, damaged or aged cells and organelles are eliminated. Beyond this homeostatic function, autophagy is ...

The autophagy machinery is thought to have an important role in the generation of peptide antigens for MHC class II molecules. The principal components of both MHC class I and class II antigen ...

Autophagy performs a self-digestion function, and its activation protects cells against certain pathogens. However, the link between the UPR and autophagy may be more complicated. These two systems ...

Different lymphomatous lesions originating in the background of AtLP thus arise from accumulated genetic changes in subclones of atypical lymphocytes. During this process, the transformed ...

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In ...

Objective To identify the best evidence on the efficacy of treatment interventions for inclusion body myositis (IBM) and to describe their safety. Methods Systematic review of randomised controlled ...

Objective The gut virome is a dense community of viruses inhabiting the gastrointestinal tract and an integral part of the microbiota. The virome coexists with the other components of the microbiota ...