Cyclic adenosine 3’,5’-monophosphate (cAMP) is a versatile secondary messenger that communicates with Guanine Nucleotide Exchange Factor (EPAC) to transfer cellular signaling and regulates numerous ...

The article reviews the current understanding of adenosine-to-inosine (A-to-I) RNA editing in cancer, highlighting its molecular mechanisms and downstream effects. It discusses the role of A-to-I ...

In a recent study in Nature Communications, researchers examined the adenosine-to-inosine (A-to-I) nucleoside editing of postmortem and live prefrontal cortical tissues. Researchers found that RNA ...

Figure 3. Conversion of TbPKAR to cyclic nucleotide specificity. a Structure of ligand binding sites of TbPKAR(199-499) mutant 6 crystallized in presence of 1mM cAMP (Supplementary Fig. 3h, PDB: 6H4G) ...

Adenosine is a nucleoside that occurs naturally in all cells of the body. Chemically it is 6-amino-9-beta-D-ribofuranosyl-9-H-purine. Skip to content. ... (cAMP). Adenosine in the brain.

Identification of Breast Cancer Survival-Related Adenosine-to-Inosine RNA Editing Sites. The Manhattan plot shows 137 ATIRE sites with p < 0.001 in the Cox-PH model for testing associations between 30 ...

Abstract. African-American (AA) men have a 60% higher incidence of prostate cancer compared to European-American (EA) men and tend to have a more aggressive clinical outcome. An understanding of the ...

Abstract. Introduction: Prostate cancer (PCa) prevalence and mortality are remarkably higher in African-American (AA)men compared to European-American (EA) men. In addition to known differences in ...

Background Adenosine to inosine (A-to-I) RNA editing is a widespread post-transcriptional RNA modification mainly located in repetitive Alu elements and mediated by the enzyme adenosine deaminase ...