Howe's side - who are in the Carabao Cup final for the second time in three years - will now play either Tottenham or Liverpool in the showpiece event on Sunday, March 16.
A Chelsea loanee scored on his AC Milan debut and Tammy Abraham added two more against his parent club to fire the hosts into the Coppa Italia semi-finals.
The 31-year-old, who previously had a loan spell with the Turkish club, departs Molineux following two years after signing an 18-month contract in Istanbul with the option of an extra year.
Jamie Carragher has named an increasingly common move that he believes should be 'banned' in the wake of Newcastle's second goal in their Carabao Cup semi-final against Arsenal.
Isak, who has repeatedly been linked with the Gunners in recent months, impressed against the visitor's defence duo of Gabriel Magalhaes and William Saliba during the semi-final.
On the heels of a January transfer window that saw Arteta fail to add attacking firepower to his squad, Neville offered a brutal assessment of the north London side's fatal flaws on the night.
Asked in a post-match interview whether injuries had played a part in Saturday's 1-0 loss, Wellens said: 'I'm not going to make excuses, I'm not Ange Postecoglou.' ...