Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

The pre‐B‐cell receptor (pre‐BCR), composed of Ig heavy and surrogate light chain (SLC), signals pre‐BII‐cell proliferative expansion. We have investigated whether the pre‐BCR also signals ...

From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

Mitochondrial complex I deficiency is associated with a wide range of clinical presentations, including Leigh syndrome. Its genetic causes are heterogeneous, with poor genotype–phenotype correlation.

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

imageimageMultiple inter- and intra-molecular interfaces stabilise the overall three-dimensional architecture of the Mis18 complex and ensure centromere localisation and function of the CENP-A loading ...

Stimulator of interferon genes (STING) is essential for innate immune pathway activation in response to pathogenic DNA. Proper activation of STING signaling requires STING translocation and ...

References and Citations As a matter of policy, the journal requires the citation of primary literature (over review articles) and, when appropriate, of data (see section on Data citation below). The ...

The peripheral anionic site on acetylcholinesterase (AChE), located at the active center gorge entry, encompasses overlapping binding sites for allosteric activators and inhibitors; yet, the molecular ...

PIF4, a phytochrome‐interacting bHLH factor, functions as a negative regulator of phytochrome B signaling in Arabidopsis ...

During bacterial cytokinesis, hydrolytic enzymes are used to split wall material shared by adjacent daughter cells to promote their separation. Precise control over these enzymes is critical to ...