Selenoprotein T (SELENOT), a selenocysteine (Sec)-containing and evolutionarily conserved protein, is anchored to the endoplasmic reticulum (ER) membrane through a hydrophobic domain (Gladyshev et al, ...

EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Motile cells can use and switch between different modes of migration. Here, we use traction force microscopy and fluorescent labeling of actin and myosin to quantify and correlate traction force ...

Neurodegenerative diseases are prevalent age-related diseases, with Alzheimer’s disease (AD) as a prototype of such conditions. As of 2024, approximately 6.9 million Americans are affected by AD, ...

In this work, we used top‐down system biology approach with causal inference analysis to reconstruct a multi‐omic network (transcriptome, metabolome, lipidome, single cell RNA sequencing) and to ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...

Astrocytes are generated from radial glial cells (RGCs) in the ventricular zone during brain development (Kriegstein and Alvarez-Buylla, 2009; Lin et al, 2021).In the dorsal neocortex, RGCs express ...

Some studies have suggested that oligomerization of IRE1 is initiated by its ER-lumenal sensor domain (Credle et al, 2005; van Anken et al, 2014; Karagoz et al, 2017; Ricci et al, 2019; Belyy et al, ...

Our study identified two fibrillarin homologs in planarian Schmidtea mediterranea, Smed-fbl-1 (fbl-1) and Smed-fbl-2 (fbl-2).We found that fbl-1 and fbl-2 are differentially expressed in neoblasts and ...

Genomes produce widespread long non-coding RNAs (lncRNAs) of largely unknown functions. We characterize aal1 (ageing-associated lncRNA), which is induced in quiescent fission yeast cells. Deletion of ...

Our study reveals significant abnormalities in lipid metabolism within lung cancer cells and identifies four distinct lipid biomarkers. Subsequently, we introduce a plasma lipid signature-based ...