Vascular ring, double aortic arch with patent right arch, and atretic proximal left arch. Left PDA, left common carotid artery, left subclavian artery, and left arterial duct supplied by a large ...

The investigation of children with early developmental impairment (EDI) is challenging in terms of selecting investigations and supporting families through the diagnostic pathway. Modern genomic ...

Determining severity of illness and undertaking an adequate risk assessment is a fundamental part of acute paediatric practice. This review highlights physiology, communication, heuristics and ...

Flow chart depicting literature search.Figure 3 Flow chart depicting literature search.

CK, creatine kinase; DAT, direct antiglobulin test; EMA, antiendomysial antibody; LDH, lactate dehydrogenase.; TSH, thyroid stimulating hormone; tTG, tissue ...

Primary ciliary dyskinesia (PCD) is a rare genetic condition with a prevalence of1:10 000 -20 000 live births.1 The prevalence is higher in certain ethnic groups due to consanguineous marriages.2 It ...

Electronic data are increasingly recorded in clinical practice. Just as advances in genetics have gradually led to clinical benefit1 so too are ‘big data’ bringing tangible advances to patient care.2 ...

Next generation sequencing (NGS), massively parallel or deep sequencing are related terms that describe a DNA sequencing technology which has revolutionised genomic research. Using NGS an entire human ...

The digital world continues to evolve and is apparent in all aspects of daily life. For children and young people, their online life is as real to them as their in-person life. Health professionals ...

Proteomics is the study of a large number of proteins in biological systems. We aim to introduce the complex field to paediatricians and present some recent examples of applications to paediatric ...

Central venous catheter (CVC) tip cultures are useful in the assessment of a patient with a potential catheter-related bloodstream infection (CRBSI). However, these results can be misleading ...

Hypoglycaemia was the third most common reason for admission of term babies to neonatal units in England in the period 2011–2013.1 Of those babies admitted with ‘hypoglycaemia’, one-third had a blood ...