A secondary stress signaling pathway in the response to optic axon injury is an unexpectedly strong contributor to both neurodegeneration and axon regenerative potential.

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...

The trial-to-trial variability of neuronal responses and the correlated response variability among neurons are modulated by visual stimulus size in a manner that depends on cortical layer, suggesting ...

Human MAP1LC3B (LC3B) binds proteins involved in autophagy and other cellular processes using a degenerate four-residue short linear motif known as the LC3-interacting region (LIR). Biochemical and ...

A detailed annotation of anatomical brain structures (some novel) of the spider Uloborus diversus is provided based on a ...

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eLife reviews research spanning behavior, morphology, evolution of developmental processes, palaeontology, experimental evolution and evolutionary theory. Learn more about what we review and sign up ...

High-throughput neutralisation tests could lead to a better understanding of the evolution of human influenza.

Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, few bona-fide MA channels have been ...

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.

This study presents fundamental findings on the evolution of extremely elongated mandibular symphysis and tusks in longirostrine gomphotheres from the Early and Middle Miocene of northern China. The ...