Indeed, patients with HF are usually complex and require comprehensive care, whereby the cornerstone of management is so‐called guidelines‐direct optimal medical therapy (OMT), particularly for ...

Cerebral ischemic injury occurs when blood flow drops below a critical level, resulting in an energy failure. The progressive transformation of hypoperfused viable tissue, the ischemic penumbra, into ...

BACKGROUND: Endothelial cell (EC) generation and turnover by self-proliferation contributes to vascular repair and regeneration. The ability to accurately measure the dynamics of EC generation would ...

The cornerstone of treatment for congestion is diuretics. 2 As stated in a 2019 position statement of the HF Association of the European Society of Cardiology, “Other than ultrafiltration, the only ...

Background—Functional tricuspid regurgitation (FTR) with structurally normal valve is of poorly defined mechanisms. Prevalence and clinical context of idiopathic FTR (Id-FTR) (without overt TR cause) ...

Real‐world data regarding clinical outcomes according to aortic stenosis (AS) management are scarce. Therefore, we aimed to investigate long‐term management across the spectrum of outpatients with AS.

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and underlies the leading causes of morbidity and mortality, both within the United States and worldwide. Commensal ...

Background: Cardiac ischemia/reperfusion (I/R) injury has emerged as an important therapeutic target for ischemic heart disease, the leading cause of morbidity and mortality worldwide. At present, ...

During human septic shock, patients are exposed to high catecholamine levels from intrinsic release and exogenous administration. Independent of sepsis, high circulating catecholamine levels can have ...

The blood-brain barrier (BBB) is a critical interface separating the central nervous system from the peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled a ...

The Get With The Guidelines-Stroke program which, began 20 years ago, is one of the largest and most important nationally representative disease registries in the United States. Its importance to the ...