The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role ... and are activated directly by G-protein-coupled receptors and indirectly by other receptors. All class I PI3Ks possess ...

Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs. You have full access to this article via your ...

PI3K signaling pathways. Upon activation by RTK, GPCR, Integrin, and Ras, p110 loses inhibition by p85 and converts PIP2 to PIP3. PIP3 recruits AKT to the cell membrane, where AKT is activated ...

Agonists that extend formation of the platelet plug generally bind to G protein-coupled receptors on the platelet surface ... We have more recently shown that arrestin-2 regulates the function of PI3K ...