The phosphatidylinositol-3-kinase (PI3K) pathway plays a crucial role ... and are activated directly by G-protein-coupled receptors and indirectly by other receptors. All class I PI3Ks possess ...

As the largest family of cell surface receptors, GPCRs account for over one-third of drug screening efforts. Inositol-1-phosphate (IP1) is a metabolite of Gq signaling and has been shown to be very ...

Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs. You have full access to this article via your ...

Image Credit: Volha_R/Shutterstock.com Proteins are nature’s functional building blocks and perform diverse tasks such as signaling, binding, and catalysis. G protein-coupled receptors (GPCRs ...

Studies Kaposi’s sarcoma herpesvirus (KSHV) G protein-coupled receptor (GPCR) contribution to metabolic regulation, trafficking and signaling, using tissue culture models and molecular biology ...