Musunuru and colleagues1 describe in the Journal an innovative approach in which gene editing is applied in the treatment of a very rare disease, the severe urea-cycle disorder carbamoyl-phosphate ...

Semaglutide at a dose of 2.4 mg has established weight-loss and cardiovascular benefits, and cagrilintide at a dose of 2.4 mg ...

In previous treat-to-target trials, adjustments to the dose of basal insulin have been made at least weekly, according to ...

Corporatization” of health care, a process predicted decades ago, now refers to the general trend throughout the industry toward higher levels of integrated control by consolidated profit-seeking ...

One of the more difficult decisions for patients with poorly controlled type 2 diabetes, as well as for their clinicians, is ...

Atopic dermatitis is a chronic disorder that usually starts in childhood but often persists in adulthood. The appearance and extent of lesions vary with age and race or ethnic group. Topical and sy ...

Explore this issue of The New England Journal of Medicine (Vol. 0 No. 0).

Genetic variation in APP, PSEN1, and PSEN2 leads to overproduction and Aβ aggregation and deposition in plaques, and this variation causes Alzheimer’s disease to adhere to a classical mendelian ...

The United States has the world’s highest incarceration rate. 1 At the end of 2020, despite historic declines in the incarcerated population due to Covid-19, 1.7 million people in the United ...

Most rotator-cuff tears are degenerative, atraumatic, and more prevalent with age. Nonoperative treatment, including physical therapy, is typically recommended; surgery is considered in some cases.

Chronic meningitis is broadly characterized as infectious or noninfectious ().Geographic region of residence, travel, immune status, and underlying illnesses are the initial building blocks for ...

A 70-year-old man was admitted to the hospital for weakness, anorexia, and weight loss. Rapidly progressive altered mental status developed shortly after admission. A diagnosis was made.