1979年，加州大学伯克利分校的一位科学家在对酵母的研究中发现了一种可以使基因座沉默的蛋白（MAR1），同年晚些时候又有三种具有类似功能的蛋白质被发现，经过统一命名，它们成为了Sir蛋白家族（沉默信息调节蛋白），而MAR1也被更名为Sir2。随着在其它各 ...

Sirtuin enzymes are a family of highly conserved protein deacetylases that depend on nicotinamide adenine dinucleotide (NAD+) for their activity. There are seven sirtuins in mammals and these proteins ...

本研究通过结构筛选发现了一种新的靶向SIRT3激活剂2APQC，并验证了2-APQC在体内外改善心力衰竭方面的显著效果。 心力衰竭(HF)是一种以心脏结构和功能异常为特征的复杂临床综合征，以心肌纤维化、心肌肥厚或其他心血管疾病为特征。心肌肥厚是对心功能障碍或 ...

本研究针对SIRT4在压力超负荷诱导的心力衰竭(HF)中的作用机制展开研究，通过构建心肌细胞特异性过表达Sirt4转基因小鼠模型，结合横向主动脉缩窄术(TAC)和线粒体靶向抗氧化剂MitoQ干预，发现SIRT4过表达通过增强活性氧(ROS)介导的促纤维化转录信号通路，加速心脏 ...

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis. This process is regulated by a family of signaling proteins called sirtuins. A recent study by ...

本研究针对围手术期神经认知障碍(PND)这一老年患者常见并发症，通过激活去乙酰化酶SIRT3，揭示了其通过调控线粒体GPX4乙酰 ...

Jellyfish, sea sponges, amoebas and other animals on the early branches of the tree of life defy conventional aging. A new study reveals diversity of proteins called sirtuins in these animals compared ...

“[...] the biological mechanisms linking aging and osteoarthritis prevalence remain largely unknown.” “In this study, we use irradiation as an acute model of ...

Cellular damage due to stress is an important factor in aging processes. It is, thus, amazing that starving, which is a stress factor per se, decelerates ageing processes and extends the lifespan of ...