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RAB33A-RhoC 轴:宫颈癌转移机制新发现与潜在治疗靶点
在小鼠淋巴结转移模型中,过表达 RAB33A 的宫颈癌细胞导致更大的转移淋巴结,敲除则导致较小的转移淋巴结。 RAB33A 促进迁移和入侵依赖活性 RhoC 水平增加:RAB33A 过表达改变了宫颈癌细胞的形态,增加了线性和片状伪足的形成。研究发现,RAB33A 过表达显著增加 ...
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