TREMs define the threshold and duration of myeloid cell responses, both promoting and attenuating myeloid cell activation and differentiation. 1 To that end, TREMs have been implicated in numerous ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

13(5626). N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y*, Xie W*, Pickering BF, Chu KL, Savino AM, Yang X, Luo H, ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...

The first patient with relapsed/refractory acute myeloid leukemia has received KJ-C2320, an allogeneic CAR T-cell therapy ...

In the introduction to their paper, the researchers detail how research in acute myeloid leukemia ... If these regulators from normal cell differentiation can be pinpointed and applied to ...