For example, specific sequences in DNA serve as binding sites for specific proteins that modulate the binding of RNA polymerase, the enzyme required for mRNA transcription. These operator ...

The journey of mRNA begins in the cell nucleus, where it is synthesized through a process called transcription: Through this process, mRNA serves as the critical link between the genetic information ...

An in-depth analysis of this transferred mRNA revealed that mRNAs coding for molecules related to transcription, translation, and stress response were transferred from mouse cells to human cells. They ...

The platform’s scalability, rapid production and relatively straightforward manufacturing process mean that mRNA therapeutics are a powerful alternative to traditional small molecule drugs and DNA ...

This suggests that mRNA moving between different mammalian ... The team also identified several key transcription factors involved in this process, with essential functions for pluripotent state ...

2 Located throughout the pre-mRNA are short, cis-acting motifs consisting of five to six nucleotides that are binding sites for RBP, which act in trans. 1,8 “When an exon that is alternatively spliced ...

Specifically, we investigate how 3′UTRs regulate protein functions in a manner that is independent of protein abundance. We found that inclusion or exclusion of the 3′UTR of an mRNA that encodes a ...

This process of protein synthesis occurs in two stages - transcription and translation. When a gene is to be expressed, the base sequence of DNA is copied or transcribed into mRNA (messenger RNA).

Optogenetic methods have so far been based almost exclusively on activating the transcription of DNA into mRNA (messenger RNA ...

Accelerated development of mRNA-based vaccine has necessitated the transformation of standard, research grade in vitro transcription reagents into raw material specifically designed and manufactured ...