Our lab has had a long-standing interest in the role and regulation of the p53 tumor suppressor. Mutations in the p53 gene (TP53) are often associated with aggressive tumor behavior and poor patient ...

A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumor suppressor p53 affect pancreatic carcinomas.

But mutations in oncogenes do not inevitably cause cancer. Normally, cells are able to “fight back” against oncogene activity through genes called tumor suppressors. When activated, tumor suppressor ...