An enigmatic yet fundamental principle of signal transduction is that parallel signalling ... review of the implications of protein kinase B/Akt signalling by Brian Hemmings and co-workers.

Rather than the PI3K/AKT pathway mediating single unidirectional ... Second, methods to combine therapeutic approaches, including signal transduction inhibitors, radiation or chemotherapy, should ...

That increased basal signaling via PI3K in the hypothalamus was ineffective in suppressing food intake suggests that cold exposure blocks signal transduction downstream of Akt as well.

The main goal of our laboratory is the identification and characterization of signal transduction pathways that cause the dysregulation of growth ... The laboratory is studying small molecules that ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both ...