Another important finding is the interaction between the SNX27-Retromer complex and the ESCPE-1 sorting complex. This interaction facilitates the transfer of cargo proteins during endosomal recycling.

Once folded, the protein travels to endosomes, where it dimerizes via its 3Fn-domains (Feb 2023 news). This beckons the retromer complex, which attaches to SORL1 C-terminal tails dangling in the ...

In this compartment, the low pH causes the dissociation of the complex, allowing the receptor to be recycled back to the Golgi through its interaction with the retromer complex for another round ...